Study explains why diabetic retinopathy is difficult to treat

Public release date: 7-Oct-2013
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Contact: Press Office
presse@helmholtz-muenchen.de
49-893-187-2238
Helmholtz Zentrum Mnchen - German Research Center for Environmental Health

Retinal damage is one of the most common complications of diabetes, affecting about 90 percent of type 1 diabetics and 75 percent of type 2 diabetics. According to the World Health Organization (WHO), diabetic retinopathy is the leading cause of blindness in adults of working age, and its incidence is showing an upward trend.

The retina is the part of the eye that converts optical images into nerve signals, which are then transmitted to the brain where vision is interpreted. Numerous proteins and molecules are involved in the process of signal transduction. Diabetic retinal damage leads to impaired function of these proteins. Within the framework of research projects of the German Center for Diabetes Research (DZD), scientists of the Research Unit Protein Science (PROT) and the Institute of Experimental Genetics (IEG) at Helmholtz Zentrum Mnchen (HMGU) have now investigated how drug treatment affects these signal carriers. They compared the concentrations of proteins in the retinas of non-diabetic mice, of mice with type 2 diabetes without treatment and of type 2 diabetic mice that were treated with the standard drug metformin, which lowers blood glucose levels and thus reduces diabetes complications. A total of 98 proteins were differentially abundant in the diabetic animals. About half of the proteins were normalized by treatment with metformin. The other proteins were unchanged, however, despite treatment and improved blood glucose levels. Among these was the protein VGLUT1, which is essential for signal transduction in specific nerve cells.

"Our results show that normalized blood glucose levels alone are not sufficient to fully treat diabetic retinopathy," said Dr. Alice Ly (PROT), lead author of the study. "In further studies we want to examine how different combination therapies affect the retinal proteins, in order to achieve a better understanding of the causes and treatment of this diabetes complication," added Dr. Stefanie Hauck (PROT). The most common diseases in the population, such as type 2 diabetes, are the focus of research at Helmholtz Zentrum Mnchen. The aim is to develop new approaches to diagnosis, treatment and prevention.

###

Further Information

Original publication:

Ly, A. et al. (2013), Retinal proteome alterations in a mouse model of type 2 diabetes, Diabetologia, doi: 10.1007/s00125-013-3070-2

Link to publication: http://link.springer.com/article/10.1007/s00125-013-3070-2/fulltext.html

As German Research Center for Environmental Health, Helmholtz Zentrum Mnchen pursues the goal of developing personalized medical approaches for the prevention and therapy of major common diseases such as diabetes mellitus and lung diseases. To achieve this, it investigates the interaction of genetics, environmental factors and lifestyle. The Helmholtz Zentrum Mnchen has about 2,100 staff members and is headquartered in Neuherberg in the north of Munich. Helmholtz Zentrum Mnchen is a member of the Helmholtz Association, a community of 18 scientific-technical and medical-biological research centers with a total of about 34,000 staff members. http://www.helmholtz-muenchen.de

The German Center for Diabetes Research (DZD) brings together experts in the field of diabetes research and interlinks basic research, epidemiology and clinical applications. Members are the German Diabetes Center in Dsseldorf, the German Institute of Human Nutrition (DIfE) in Potsdam-Rehbrcke, Helmholtz Zentrum Mnchen German Research Center for Environmental Health, the Paul Langerhans Institutes of the University Hospital Carl Gustav Carus in Dresden and the University of Tbingen, as well as the Gottfried Wilhelm Leibniz Association and the Helmholtz Association of German Research Centres. The objective of the DZD is to find answers to open questions in diabetes research by means of a novel, integrative research approach and to make a significant contribution to improving the prevention, diagnosis and treatment of diabetes mellitus. http://www.dzd-ev.de

The independent Research Unit Protein Science (PROT) investigates the composition of protein complexes and their integration into cellular processes and protein networks. One focus is the analysis of the interaction of genetic variance and environmental factors in neurodegenerative and metabolic diseases. The aim of this research is to identify biological systems and disease-associated disorders on a systemic level, thus contributing to a molecular understanding of diseases.

The research objective of the Institute of Experimental Genetics (IEG) is to elucidate the causes and pathogenesis of human diseases. Due to its prominent role in interdisciplinary and international consortia, the IEG is a global leader in the systemic study of mouse models for human diseases and the elucidation of involved genes. The main focus is on metabolic diseases such as diabetes. The IEG is part of the Helmholtz Diabetes Center (HDC).

Scientific Contact

Dr. Stefanie Hauck
Helmholtz Zentrum Mnchen - German Research Center for Environmental Health (GmbH)
Research Unit Protein Science
Ingolstdter Landstr. 1, 85764 Neuherberg
Tel.: 089-3187-3941
E-Mail: hauck@helmholtz-muenchen.de

Prof. Dr. Marius Ueffing
Helmholtz Zentrum Mnchen - German Research Center for Environmental Health (GmbH)
Research Unit Protein Science
Ingolstdter Landstr. 1, 85764 Neuherberg
Tel.: 089-3187-3567
E-Mail: marius.ueffing@helmholtz-muenchen.de

---

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 7-Oct-2013
[ | E-mail | Share ]

Contact: Press Office
presse@helmholtz-muenchen.de
49-893-187-2238
Helmholtz Zentrum Mnchen - German Research Center for Environmental Health

Retinal damage is one of the most common complications of diabetes, affecting about 90 percent of type 1 diabetics and 75 percent of type 2 diabetics. According to the World Health Organization (WHO), diabetic retinopathy is the leading cause of blindness in adults of working age, and its incidence is showing an upward trend.

The retina is the part of the eye that converts optical images into nerve signals, which are then transmitted to the brain where vision is interpreted. Numerous proteins and molecules are involved in the process of signal transduction. Diabetic retinal damage leads to impaired function of these proteins. Within the framework of research projects of the German Center for Diabetes Research (DZD), scientists of the Research Unit Protein Science (PROT) and the Institute of Experimental Genetics (IEG) at Helmholtz Zentrum Mnchen (HMGU) have now investigated how drug treatment affects these signal carriers. They compared the concentrations of proteins in the retinas of non-diabetic mice, of mice with type 2 diabetes without treatment and of type 2 diabetic mice that were treated with the standard drug metformin, which lowers blood glucose levels and thus reduces diabetes complications. A total of 98 proteins were differentially abundant in the diabetic animals. About half of the proteins were normalized by treatment with metformin. The other proteins were unchanged, however, despite treatment and improved blood glucose levels. Among these was the protein VGLUT1, which is essential for signal transduction in specific nerve cells.

"Our results show that normalized blood glucose levels alone are not sufficient to fully treat diabetic retinopathy," said Dr. Alice Ly (PROT), lead author of the study. "In further studies we want to examine how different combination therapies affect the retinal proteins, in order to achieve a better understanding of the causes and treatment of this diabetes complication," added Dr. Stefanie Hauck (PROT). The most common diseases in the population, such as type 2 diabetes, are the focus of research at Helmholtz Zentrum Mnchen. The aim is to develop new approaches to diagnosis, treatment and prevention.

###

Further Information

Original publication:

Ly, A. et al. (2013), Retinal proteome alterations in a mouse model of type 2 diabetes, Diabetologia, doi: 10.1007/s00125-013-3070-2

Link to publication: http://link.springer.com/article/10.1007/s00125-013-3070-2/fulltext.html

As German Research Center for Environmental Health, Helmholtz Zentrum Mnchen pursues the goal of developing personalized medical approaches for the prevention and therapy of major common diseases such as diabetes mellitus and lung diseases. To achieve this, it investigates the interaction of genetics, environmental factors and lifestyle. The Helmholtz Zentrum Mnchen has about 2,100 staff members and is headquartered in Neuherberg in the north of Munich. Helmholtz Zentrum Mnchen is a member of the Helmholtz Association, a community of 18 scientific-technical and medical-biological research centers with a total of about 34,000 staff members. http://www.helmholtz-muenchen.de

The German Center for Diabetes Research (DZD) brings together experts in the field of diabetes research and interlinks basic research, epidemiology and clinical applications. Members are the German Diabetes Center in Dsseldorf, the German Institute of Human Nutrition (DIfE) in Potsdam-Rehbrcke, Helmholtz Zentrum Mnchen German Research Center for Environmental Health, the Paul Langerhans Institutes of the University Hospital Carl Gustav Carus in Dresden and the University of Tbingen, as well as the Gottfried Wilhelm Leibniz Association and the Helmholtz Association of German Research Centres. The objective of the DZD is to find answers to open questions in diabetes research by means of a novel, integrative research approach and to make a significant contribution to improving the prevention, diagnosis and treatment of diabetes mellitus. http://www.dzd-ev.de

The independent Research Unit Protein Science (PROT) investigates the composition of protein complexes and their integration into cellular processes and protein networks. One focus is the analysis of the interaction of genetic variance and environmental factors in neurodegenerative and metabolic diseases. The aim of this research is to identify biological systems and disease-associated disorders on a systemic level, thus contributing to a molecular understanding of diseases.

The research objective of the Institute of Experimental Genetics (IEG) is to elucidate the causes and pathogenesis of human diseases. Due to its prominent role in interdisciplinary and international consortia, the IEG is a global leader in the systemic study of mouse models for human diseases and the elucidation of involved genes. The main focus is on metabolic diseases such as diabetes. The IEG is part of the Helmholtz Diabetes Center (HDC).

Scientific Contact

Dr. Stefanie Hauck
Helmholtz Zentrum Mnchen - German Research Center for Environmental Health (GmbH)
Research Unit Protein Science
Ingolstdter Landstr. 1, 85764 Neuherberg
Tel.: 089-3187-3941
E-Mail: hauck@helmholtz-muenchen.de

Prof. Dr. Marius Ueffing
Helmholtz Zentrum Mnchen - German Research Center for Environmental Health (GmbH)
Research Unit Protein Science
Ingolstdter Landstr. 1, 85764 Neuherberg
Tel.: 089-3187-3567
E-Mail: marius.ueffing@helmholtz-muenchen.de

---

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?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-10/hzm--sew100713.php

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This Man Puts All Others To Shame By Planning Girlfriend?s Dream Wedding From Her Pinterest Boards

• 
• 

Ryan Leak, are you for real or are you a figment of the female imagination?? Bow down to the man who overheard his girlfriend Amanda Roman saying that her secret dream was to get engaged and married on the same day and got to work making that shit happen. Not only did Leak figure out how to navigate his way around Pinterest (a skill that I have yet to master), but he managed to plan their wedding entirely from 224 re-Pins in her ?My Dream Wedding? folder. WITHOUT HER KNOWING.

?I always knew I wanted an extravagant wedding, but I never anticipated doing anything as drastic as this. For over a year I had to arrange to take calls in private and was forced to put locks on my phone just in case she saw anything. We had around 100 guests and apparently over ,1000 people knew what I was planning so it?s pretty amazing she didn?t find out,? said Leak.

I mean, come on! Congrats to the couple. I look forward to seeing what Ryan is planning for their anniversary because as much as he killed the whole engagement/wedding, he?s kind of screwed himself for life. Because how do you top that? [Jezebel]

Source: http://www.thefrisky.com/2013-10-03/this-man-puts-all-others-to-shame-by-planning-girlfriends-dream-wedding-from-her-pinterest-boards/

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Blocksy wants to take a bite out of Zillow?s Big Apple

By bringing ?joy? to the user experience of a listing site, Blocksy intends to snap up market share from old-guard listing sites that preside over the Big Apple, including heavyweight Zillow acquisition StreetEasy.

?Blocksy represents a sort of counterbalance to ? ensure that you don?t see runaway advertising prices? or ?abuse of its leverage on the part of StreetEasy and Zillow,? said Jason White, co-founder of Blocksy.

Learn more about the site, which carries both rental and for-sale listings, and the free, innovative marketing tools that it offers to agents:

Source: http://feedproxy.google.com/~r/inmannews/~3/DSsn42hXOu4/

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Now at your library: Streaming movies, music

In this Sept. 11, 2013 photo, Kirk Blankenship, Electronic Resources Librarian for Seattle Public Libraries, poses for a photo in the DVD shelving area of the library as he holds a tablet with the website for streaming-media company Hoopla, which the library is using to offer patrons free access to streaming movies, music, and audiobooks. (AP Photo/Ted S. Warren)

In this Sept. 11, 2013 photo, Kirk Blankenship, Electronic Resources Librarian for Seattle Public Libraries, poses for a photo in the DVD shelving area of the library as he holds a tablet with the website for streaming-media company Hoopla, which the library is using to offer patrons free access to streaming movies, music, and audiobooks. (AP Photo/Ted S. Warren)

In this Sept. 11, 2013 photo, Kirk Blankenship, Electronic Resources Librarian for Seattle Public Libraries, poses for a photo in the DVD shelving area of the library as he holds a tablet with the website for streaming-media company Hoopla, which the library is using to offer patrons free access to streaming movies, music, and audiobooks. (AP Photo/Ted S. Warren)

In this Sept. 11, 2013 photo, Kirk Blankenship, Electronic Resources Librarian for Seattle Public Libraries, poses for a photo outside the library as he holds a tablet with the website for streaming-media company Hoopla, which the library is using to offer patrons free access to streaming movies, music, and audiobooks. (AP Photo/Ted S. Warren)

In this Sept. 11, 2013 photo, Kirk Blankenship, Electronic Resources Librarian for Seattle Public Libraries, poses for a photo as he holds a tablet with the website for streaming-media company Hoopla, which the library is using to offer patrons free access to streaming movies, music, and audiobooks. (AP Photo/Ted S. Warren)

In this Sept. 11, 2013 photo, Jamie Koepnick-Herrera holds her daughter Paloma, 1 1/2, as they browse for a video to watch on the Seattle Public Library's Hoopla streaming media website. The library is using Hoopla to offer patrons free access to streaming movies, music, and audiobooks. (AP Photo/Ted S. Warren)

SEATTLE (AP) ? There's a new source to stream movies and other digital content, and it's not a tech company with tens of thousands of titles. It's something more familiar, and might even be just down the street: the public library.

Often thought of as stodgy brick-and-mortar havens for bibliophiles, libraries are trying out a new service that allows patrons to check out streaming movies, music, TV shows and audiobooks from anywhere they want.

It works similarly to Netflix: Through an app on a tablet or a browser on a personal computer, users can peruse dozens of movies and click on a film to "borrow" it. The content starts streaming, for free.

While libraries are already loaning e-books, the move to streaming is part of a larger shift for them to remain relevant in a digital world.

Libraries are "meeting patrons where they want to access content," said Kirk Blankenship, Electronic Resources Librarian for Seattle Public Libraries, which is using the service called Hoopla.

The service, from Ohio-based Midwest Tape, LLC, is also being used in Los Angeles, Salt Lake City, Topeka, Kan., and several others towns and cities nationwide. Hoopla launched in full in May with 20 library systems.

As of early September, there are about 220,000 people using the app, said Michael Manon, Hoopla's brand manager. The goal is to reach 100 library systems by year's end.

Libraries have always been a source of audiovisual entertainment. A 2012 Pew Research Center survey found that among patrons 16 years old and older, 40 percent visited libraries to borrow movies. Another 16 percent borrowed music.

In the Seattle area, DVDs and CDs of popular titles can have queues of hundreds of people waiting to check them out. E-books have been offered for years now.

"Public libraries do not have the budgets to compete with Amazon, Comcast, and Netflix and will not be able to pay a premium for online content," Blankenship said, adding that DVDs will continue to be the best way to offer popular movies.

Updating and maintaining that physical collection takes time and money. It also means libraries have to pay for the media upfront, while Hoopla allows them to pay per time a title is borrowed.

Those costs depend on the type of media and its release date, and range from 99 cents to $2.99. Seattle libraries have allocated $10,000 a month limit so far for Hoopla items and patrons are limited to 20 checkouts a month, Blankenship said.

That limit may change, depending on demand and how usage grows. Hoopla's launch won't affect the stocking of physical DVDs at library branches for the time being, Blankenship said.

For Seattle resident and library patron Jamie Koepnick-Herrera, Hoopla has joined her other streaming services such as Netflix, which she uses for movies, and Hulu, which she uses to watch current seasons of television shows. On Hoopla, she found the yoga videos she was looking for.

"I think it provides a great free source of entertainment for families who can't afford to get a movie for family night or for teenagers to have access to that album they can't afford," Koepnick-Herrera said.

Hoopla's movie and television collection is impressive in its numbers: About 3,000 titles.

It is, however, chockfull of B-movies. Some of the newer movies weren't exactly hits in the theaters, such as Keanu Reeves' "Generation Um" and Lee Daniels' "The Paperboy," which preceded his hit "The Butler."

But there are also many older films, including some classics and a healthy choice of foreign flicks. The collection also includes documentaries, such as "Gasland" and "Restrepo," and public television documentaries, like Ken Burn's "Prohibition."

Hoopla offers plenty of National Geographic and British TV shows, but not much else from TV.

There are also educational choices, such as preparation videos for high school advanced placement exams.

On the music side, the choices are far greater and newer ? about 300,000 titles.

"The music industry is more attuned to the digital," Hoopla's Manon said. "Unfortunately, for movies and television, the owners are a bit more apprehensive."

So far, Hoopla is available on Apple and Android products. They are developing apps for Xbox and Chromecast next.

___

Manuel Valdes can be reached at http://twitter.com/ByManuelValdes

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/495d344a0d10421e9baa8ee77029cfbd/Article_2013-10-02-US-TEC-Streaming-Movies-Libraries/id-ea2cb9daff8a44b582985e1fad784531

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DeathBrand

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Sorry, we're closed: Government shutdown ripples across the country

Families across the nation are already feeling the effects of the government shutdown, from the cessation of processing passports to closed national parks. NBC's Peter Alexander reports.

By Matthew DeLuca, Staff Writer, NBC News

The impact of the first government shutdown in 17 years was felt across America on Tuesday as offices were shuttered and workers were sent home after lawmakers failed to come to a deal to?keep the lights on.

The Statue of Liberty closed its doors, fountains on the National Mall trickled out and the beloved "panda-cam" at the National Zoo went dark, all effects of Congress' inability?to?keep the government funded. The Centers for Disease Control said it would see ?significant impact? to its operations as a result of the shutdown, and government employees feared the long-term effects on their income with no end in sight.

Voters voiced their anger on Tuesday about the shutdown, which came after lawmakers reached an impasse on a bill to finance the government past Sept. 30. The Senate rejected measures passed by the Republican-led House on Monday that would have delayed key portions of the Affordable Care Act while extending funding for a few weeks.

?I?m annoyed as I start my 5:30 a.m. shift of my second job (while going to school) that you?re just not showing up to work,? Sam Budzisz wrote on Twitter with the hashtag #DearCongress.

?Thanks for the shutdown and lack of pay,? Twyla Strogen said in another tweet. ?We, the public, your bosses, will return the favor at the polls.?

The Senate reconvened at 9:30 a.m. ET on Tuesday after the House requested a bipartisan conference of lawmakers be convened to hash out the crisis ? a plan immediately rejected by Democratic Senate Majority Leader Harry Reid.

The shutdown was expected to have sweeping effects across the nation as hundreds of thousands of federal employees faced indefinite furloughs, tourist destinations shut down and services including food assistance and IRS audits are disrupted. The Bureau of Labor Statistics, which collects employment numbers, said on its website that it would not ?collect data, issue reports, or respond to public inquiries? for the length of the shutdown.

Orange Room host Carson Daly asks visitors to the TODAY plaza and Twitter users viewing at home to share their #DearCongress messages with TODAY.

Senators? state offices shut down, including those of Democratic Senator Tom Carper of Delaware, whose office said in an email that his staff would not be able to answer calls or respond to other requests from constituents for the duration of the shutdown.

President Obama blamed the government shutdown on a ?faction? of House Republicans in a statement from the White House on Tuesday.

?They?ve shut down the government over an ideological crusade to deny affordable health insurance to millions of Americans,? the president said. ?In other words they demanded ransom just for doing their job.?

Senate Republican Leader Mitch McConnell blamed Democrats, saying that they ?dragged their feet for days? and rejected bills passed by the House that would have kept the government funded, if only for a little while.

Barricades were set to go up around the National Mall, NBC Washington reported.

?We have 3,000 permitted events on the Mall every year,? Carol Johnson with the National Park Service told the station. ?While the government is shut down, all of those events have to be canceled,? she said, including an ?honor flight? Tuesday of veterans from Mississippi. Visitors walked freely around the memorial after a group of visiting veterans bypassed the barricade on Tuesday morning, but remained technically closed.

A number of District restaurants and at least one Pilates studio is offering free or discounted services to furloughed federal employees for as long as the shutdown lasts, NBC Washington reported.

?It?s a mess, Congress needs to get their act together. Seriously, they?re like kids on the playground, fighting, fighting for nothing. It?s ridiculous,? said Leathey Chandler, an employee at the Department of Agriculture. ?It was ridiculous then and it?s ridiculous now. Get it together, people.?

Another USDA employee, Lawrence Albert, said he was going into work to set up an email away message and change his voicemail before heading home.

?I think it?s miserable, it has nothing to do with democracy or lobbying for causes,? Albert said. ?This is not the way government should work at all, it?s a disgrace.?

Employees feared furloughs at Joint Base Lewis-McChord in Washington state on Tuesday, where 16,000 civilians work, according to Seattle NBC News affiliate King 5. The base released a statement on Monday saying that civilian employees should report to work on Tuesday, but did not say who would be considered essential enough to stay on.

?How much more does the federal employee have to endure?? base employee Matthew Hines asked, according to King 5. ?We?ve already been jerked around.?

Jason Reed / Reuters

Security personnel are pictured at the Lincoln Memorial in Washington, October 1, 2013.

The CDC would completely close the ?vast majority? of its operations, it announced in a release on Tuesday morning. The shutdown would lead to a slower response to public health issues, and its activity monitoring diseases, including flu season, will be severely slashed.

The shutdown had some immediate international repercussions as the American Battle Monuments Commission, which manages two dozen U.S. military cemeteries in foreign nations, closed all of its monuments and memorials.

Tourist destinations in New England braced for the full impact of the shutdown, darkening the Fanueil Hall Visitor Center in Boston and closing down Acadia National Park in Maine, according to the Boston Globe.

?It?s going to be a kind of ripple effect,? Sean Hennessey, spokesman for the National Park Service, told the newspaper. ?There?s a significant economic impact that our national parks have in their communities.?

A capacity football game between the Naval and Air Force academies on Saturday could be in danger of being canceled, Maryland newspaper the Capital Gazette reported. Naval Academy associate athletic director Scott Strasemeier said that all intercollegiate matchups between the service academies had been suspended by the defense department, according to the paper.

Army is scheduled to play Boston College in Chestnut Hill, Mass., on Saturday.

"We have been in close communication with Army athletics officials regarding the potential effect of the government shutdown on this Saturday's football game," Boston College said in a statement on Tuesday, adding that the two schools had not reached a resolution. "Obviously our intention is to exhaust all possibilities to play the game."

Ohio resident Maureen Brown told local affiliate NBC 4 that she was worried about the effect that shutdown would have on government workers in her area.

?You think the government is a secure job that you don?t have to worry about stuff like that, but nowadays you do, nothing is secure anymore,? Brown, herself a former government employee, told the affiliate. ?If they don?t work then they don?t go shopping, they don?t buy a house and that affects everybody and it makes the economy worse than it is.?

The shutdown found a supporter in Missoula, Mont., where resident Dennis Curtis told NBC Montana that he believed it would help cut costs.

?We really need a shutdown and we need a shutdown for months,? Curtis said. ?How long are we going to continue to borrow from China and Japan and all of these other countries because we just can?t do it? We?re going to collapse this country.?

Many others said that even a short-term furlough could cut deep into their finances, including 23-year-old park ranger Darquez Smith.

?I?ve got a lot on my plate right now ? tuition, my daughter, bills,? Smith, a ranger at Ohio?s Dayton Aviation Heritage National Historical Park, told the Associated Press. ?I?m just confused and waiting just like everyone else.?

Department of Veterans Affairs employee Marc Cevasco told the AP he was going to work on Tuesday, but planned to be furlough indefinitely after that.

?Even if it?s just shut down for a week, that?s a quarter of your pay this month. That means a lot to a lot of people,? Cevasco, 30, told the news service.

Twenty-eight poison ivy-eating goats were removed from the Gateway National Recreation Area in New Jersey after their owner became worried that a government shutdown would shutter the park where the goats had been recruited to eat the pesky weed, according to the Asbury Park Press. The goats had been a ?tremendous hit? with parkgoers, the president of the Sandy Hook Foundation told the paper.

NBC News? Carrie Dann and Michael O?Brien contributed to this report.The Associated Press and Reuters contributed to this report.

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This story was originally published on Tue Oct 1, 2013 8:51 AM EDT

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Tutorial - Recording Computer Playback on Windows/es

Para grabar reproducciones del computador, Audacity depende de su dispositivo de audio para que haga una entrada disponible para grabar reproducciones. Este es el caso usual en m?quinas antiguas con Windows, por lo que solo requiere seleccionar la entrada correcta en Audacity.

Debido a problemas de derechos de autor, los computadores actuales usualmente no tienen una entrada para grabar reproducciones del computador, o debe ser activada especialmente desde fuera de Audacity.

Este tutorial por ello presenta varias opciones para grabar reproducciones del computador. Por favor siempre respete los derechos de autor de otros al grabar.

Escogiendo la entrada en Audacity

Escoja la entrada deseada para grabar la reproducci?n de computador en la tercera caja (Dispositivo de entrada) de la Barra de herramientas de dispositivos. La caja de dispositivo de entrada est? seleccionada (en azul) en la imagen a continuaci?n:

Usted tambi?n puede seleccionar este dispositivo de entrada en Dispositivo de grabaci?n en las Preferencias de dispositivos.

• Si el dispositivo de sonido del computador provee una entrada para grabar reproducciones del computador, escoja su nombre. Esta puede ser llamada "Stereo Mix", "Wave Out", "Sum", "What U Hear", "Loopback" o tener otro nombre. El nombre exacto y si esa entrada est? disponible depende ?nicamente de los controladores de su dispositivo de audio.
• En Windows Vista, Windows 7 o Windows 8 ?nicamente usted puede elegir el servidor Windows WASAPI (en la primera caja de la Barra de herramientas de dispositivo) y luego la entrada (loopback) en la caja de Dispositivo de entrada. Escoja la entrada de bucle de retorno para su dispositivo de sonido del computador al que escuchar? (por ejemplo, "Speakers (loopback)" ). La entrada de bucle de retorno graba la reproducci?n del computador incluso si el dispositivo de sonido carece de su propia mezcla est?reo o entrada similar.

  N?tese que el deslizador de volumen de entrada de la Barra de herramientas de mezcla (y posiblemente el deslizador de salida tambi?n) ser? atenuada al seleccionar el servidor de Windows WASAPI. Para controlar el nivel de grabaci?n, ajuste el nivel de salida del audio. Esto se logra mejor en la aplicaci?n que est? reproduciendo el audio, por ejemplo el reproductor de audio o video en el sitio web desde el que est? grabando. Si el deslizador de salida de Audacity puede controlar el volumen del audio que usted escucha mientras graba, no afectar? el nivel al que est? grabando.

• Avanzado: Puede ver informaci?n sobre los otros servidores de Audio aqu?. WDM-KS puede sufrir de un bajo nivel de entrada al grabar reproducciones del computador.

Usted debe reproducir el audio que desea grabar usando la misma tarjeta de sonido que tiene la entrada de mezcla est?reo o similar. Usted no puede reproducir audio a trav?s de un aud?fono o parlante USB y luego grabar esa reproducci?n usando la entrada de mezcla est?reo del dispositivo de sonido integrado.

Salga de Audacity y contin?e leyendo abajo si no ve una entrada para grabar reproducciones del computador.

Panel de control de Windows para sonidos

Los computadores con Windows Vista, Windows 7 y Windows 8 casi siempre tienen solo entradas de micr?fonos activadas por defecto. Los sistemas anteriores con Windows tambi?n necesitar?an que se muestre una entrada para grabar reproducciones de computador antes de que Audacity pueda usarla. Para mostrar o activar entradas, lance el panel de control del dispositivo desde el panel de control de Windows o desde la bandeja del sistema (al lado del reloj).

• Windows Vista, Windows 7 y Windows 8

1. Haga clic derecho sobre el al lado del reloj del sistema y luego elija para abrir la pesta?a de Grabaci?n de "Sonido".
2. Haga clic derecho en cualquier parte dentro de la pesta?a de Grabaci?n y escoja "Mostrar dispositivos desactivados" y luego haga clic derecho nuevamente y escoja "Mostrar dispositivos desconectados".
3. Haga clic derecho espec?ficamente sobre el dispositivo de entrada con el que desea grabar (en este caso "Mezcla est?reo" u otra alternativa que tenga), y si est? visible, escoja "Activar".
4. A veces ayuda hacer clic derecho sobre la "Mezcla est?reo" o dispositivo similar nuevamente y elegir "Ajustar dispositivo como predeterminado".
5. Si usted necesita m?s ayuda, vea estas instrucciones Wiki para Windows Vista, Windows 7 y Windows 8.

1. Haga clic derecho sobre el al lado del reloj del sistema y luego elija .
2. En las "Propiedades de dispositivos de audio y sonido" o similar, haga clic en la , luego en el , seleccione el "Dispositivo predeterminado" desde el que est? intentando grabar (este probablemente tendr? el nombre de su dispositivo de sonido integrado).
3. Apriete el bot?n .
4. Si usted puede ver una opci?n de Mezcla est?reo o similar, intente apretar en su caja para seleccionarla.
5. En caso contrario, elija y luego .
6. En la ventana que aparece, apriete el bot?n de radio "Grabaci?n", luego en "Mostrar los siguientes controles de volumen", haga clic en la caja para mezcla est?reo o similar, y luego en "Aceptar".
7. Si usted necesita m?s ayuda, vea estas instrucciones Wiki para Windows XP.

RealTek y otros paneles de control de tarjeta de sonido

Si usted a?n no tiene entrada de Mezcla est?reo en Windows, a veces esta entrada puede ser activada en el panel de control propio de la tarjeta de sonido, especialmente con dispositivos RealTek antiguos. El panel de control propio de la tarjeta de sonido puede ser encontrado en el panel de control de Windows. Consejos para paneles de control de RealTek:

• Algunos paneles "seleccionan" una entrada silenciando todas salvo una, por lo que en este caso, silencie todo excepto Mezcla est?reo
• Si usted no ve Mezcla est?reo, apriete el ?cono de la llave inglesa y active Mezcla est?reo en el di?logo que aparece
• En algunos paneles la opci?n para elegir es "Enabled recording multi-streaming"
• Usted debiera ahora ver un control de volumen para Mezcla est?reo; aseg?rese que est? seleccionado o no silenciado.

Actualizando controladores del dispositivo de sonido

Si a?n no hay una entrada adecuada, intente actualizar los controladores del dispositivo de sonido para su tarjeta de sonido. Esto puede a veces producir una entrada adicional para grabar reproducciones del computador, y puede arreglar otros problemas cono baja calidad o saltos.

Cable de retroalimentaci?n

Un m?todo alternativo de grabar audio reproduci?ndose en el computador es comprar un cable con conectores est?reos de 1/8 inch (3.5 mm) en cada extremo. Cables adecuados est?n disponibles en casi toda tienda de audio. Conecte un extremo del cable a la salida de audio (verde) del computador y el otro extremo a la entrada de l?nea (azul). Luego escoja la entrada de l?nea como el dispositivo de entrada en Audacity.

Para escuchar lo que se est? reproduciendo mientras graba, compre un adaptador est?reo de una a dos entradas para conectarlo a la salida de audio. Esto le da un conector libre al cual conectar los parlantes o aud?fonos.

Programas alternativos para grabar reproducciones del computador

Usted puede usar otros programas para grabar reproducciones del computador que no dependen de que el dispositivo de sonido del computador tenga la capacidad. Estos programas crear?n un archivo de audio que puede ser luego importado a Audacity para ser editado.

Todas las opciones a continuaci?n toman el audio digital desde la aplicaci?n que produce el sonido. Esto tiene ventajas sobre grabaciones de Mezcla est?reo. Se evitan las conversiones con p?rdida de digital a an?logo a digital y los sonidos y alertas del sistema no deseados no son capturados.

• SoundLeech es un programa que corre desde la bandeja del sistema. Graba solo al formato sin p?rdida WAV.
• TotalRecorder es un paquete de grabaci?n de bajo costo. Las transmisiones por internet pueden ser opcionalmente capturadas a una velocidad m?s r?pida que al normal (el monitoreo no est? disponible en ese modo).

Tarjetas de sonido externas

Otra alternativa es una tarjeta de sonido externa por USB con una opci?n del tipo de "Mezcla est?reo". Un ejemplo que funciona en todas las versiones de Windows es "Trust Sound Expert External". No todas las tarjetas de sonido externas USB ofrecen una opci?n de Mezcla est?reo, por lo que debe leer cuidadosamente las especificaciones antes de comprar.

Enlaces

|< Tutorial - Grabando audio reproduci?ndose en el computador

Source: http://manual.audacityteam.org/m/index.php?title=Tutorial_-_Recording_Computer_Playback_on_Windows/es&diff=28154&oldid=28060

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Facebook's new mobile ad format keeps users coming back to familiar apps

Ads for mobile apps are frequently ineffective after the first viewing -- once users install a given app, they rarely have incentives to try the software again. Facebook may have found a way to sustain customers' interest through its new deep linking ad format, however. The approach takes curious visitors to a specific point in an already installed Android or iOS app. A hotel ad can invite you to book a room, for example, while a game ad may take you to a new level pack. We can't promise that the sales pitches will be any more persuasive than before, but they may remind you of installed apps that were previously collecting virtual dust.

Source: http://www.engadget.com/2013/10/02/facebook-deep-link-mobile-ads/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget&ncid=rss_semi

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Apple overtakes Coca-Cola as world's most valuable brand; Google No. 2

Apple (AAPL) has unseated Coca-Cola as the world's No. 1 brand, as the company founded by Steve Jobs is a leader in design and performance, according to a study of the Top 100 brands by Interbrand.

Apple's brand value jumped 28 percent to $98.3 billion and Google's (GOOG) rose to second place at $93.3 billion. The Coca-Cola name slipped from the top spot after 13 years to third place at $79.2 billion.

"Every so often, a company changes our lives -- not just with its products, but with its ethos," Jez Frampton, chief executive officer at New York-based brand consultancy Interbrand, said in a statement. Current Apple CEO "Tim Cook has assembled a solid leadership team and has kept Steve Jobs' vision intact -- a vision that has allowed Apple to deliver on its promise of innovation time and time again."

The annual study, closely watched by the industry, determines a brand's value by examining its financial performance, role in influencing consumer buying and ability to secure earnings. The Top 10 is rounded out in descending order by IBM, Microsoft, GE, McDonald's, Samsung, Intel (INTC) and Toyota. The 100 have a combined value of $1.5 trillion, an 8.4 percent increase from last year.

Technology names were among the biggest climbers -- and the biggest decliners as well. Google's brand value rose 34 percent and Samsung's advanced 20 percent. Meanwhile, Nokia dropped to 57th place from 19th with the largest decline in brand value in the history of the 14-year study. Yahoo (YHOO) and BlackBerry fell off the rankings altogether.

The shifts in many of the brands' placements reflects the turmoil in the technology industry over the past year. Nokia -- which had the largest share of the mobile-handset market until it was overtaken by Samsung Electronics in 2012 -- was split this month when Microsoft agreed to buy the Finnish company's phone business for $7.34 billion. As part of the deal, Microsoft licensed the Nokia brand for a decade just for the low-end models. Fancier devices won't get the Nokia name any more.

Last week, smartphone pioneer BlackBerry said a group led by Toronto-based insurance company Fairfax Financial Holdings signed a letter of intent for a $4.7 billion buyout. The company is cutting a third of its staff and refocusing just on business customers after the products once so popular they were known as CrackBerries lost favor to Apple and Samsung handsets, which offered better Web browsing and wider ranges of applications.

New names on the Interbrand list include Discovery, Duracell and Chevrolet. The fastest-rising brands were Apple, Facebook, Prada, Google and Amazon.

Top 10 brands

1. Apple
2. Google
3. Coca-Cola
4. IBM
5. Microsoft
6. GE
7. McDonald's
8. Samsung
9. Intel
10. Toyota

Source: http://www.siliconvalley.com/ci_24207718/apple-overtakes-coca-cola-worlds-most-valuable-brand?source=rss_viewed

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Mountain View senior commits to Gonzaga baseball

Source: http://feedproxy.google.com/~r/IdahostatesmancomHighSchoolSports/~3/tMJwV9To_BE/mountain-view-senior-commits-to.html

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Video: Global markets: Europe shares move higher

Sorry, Readability was unable to parse this page for content.

Source: http://www.nbcnews.com/video/cnbc/53153859/

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Dartmouth researchers receive $5.9 million grant from NIH for lung research

Public release date: 30-Sep-2013
[ | E-mail | Share ]

Contact: Derik Hertel
kenneth.d.hertel@dartmouth.edu
603-650-1211
The Geisel School of Medicine at Dartmouth

Award strengthens pioneering work in cystic fibrosis at Dartmouth's Geisel School of Medicine

Hanover, N.H.The National Institutes of Health (NIH) has awarded a $5.9 million grant to support an Institutional Development Award (IDeA) Lung Biology Center of Biomedical Research Excellence (COBRE) at the Geisel School of Medicine at Dartmouth.

For the past 10 years, COBRE funding has supported the Center's work, which has contributed not only to our understanding of cystic fibrosis and to the development of patented and patent-pending therapeutic approaches for treating the disease, but to other chronic lung diseases. Lung disease is the third most frequent cause of death in the United States.

Directed by Principal Investigator Bruce Stanton, PhD, professor of microbiology and immunology at Geisel, the Lung Biology Center draws on the expertise and dedication of more than 100 faculty, students, and research associates working in 32 laboratories.

"Continued federal funding for the Lung Biology Center is very important to the Geisel School of Medicine and I applaud Bruce Stanton for his leadership," says Duane Compton, PhD, senior associate dean for research and professor of biochemistry at Geisel. "He has built a center that translates the best basic science into clinical application, and which also supports core facilities that sustain our researchers."

With the federal budget sequester taking a toll on biomedical research nationally, this five-year grant award reflects recognition of the quality of the medical research being done at Dartmouth, and provides the resources necessary to support the core services and pilot programs that will enable the Center to continue its work.

"The Lung Biology Center has spearheaded the development and mentoring of a cadre of physician-scientists engaged in cystic fibrosis research," says Stanton. "Their approaches are closely aligned with the goals of the Dartmouth SYNERGY Program in Clinical and Translational Science, which focuses on moving therapeutic advances from the research bench to the patient's bedside."

"This NIH grant demonstrates the strength of Geisel's overall research enterprise, and the excellent discovery taking place around cystic fibrosis and other chronic lung diseases," says Wiley "Chip" Souba, MD, MBA, ScD, dean of Dartmouth's Geisel School of Medicine. "While the sequester is forcing research cuts at many universities, research funding to the medical school just reached an all-time high, with $140 million in total grant funding for fiscal year 2013."

The Lung Biology Center is one of four Dartmouth Centers receiving COBRE support from the National Institute of General Medical Sciences Institutional Development Award Program (IDeA). The others include Immunology, Quantitative Biomedical Sciences, and Molecular Epidemiology. All COBRE programs share expertise and experience with each other, with the New Hampshire-INBRE (IDeA Network of Biomedical Research Excellence), and with partner programs at the University of Vermont and the Mt. Desert Island Biological Laboratory in Maine.

The IDeA program builds research capacities in states that historically have had low levels of NIH funding by supporting basic, clinical, and translational research; faculty development; and infrastructure improvements.

###

The Geisel School of Medicine at Dartmouth, founded in 1797, strives to improve the lives of the communities it serves through excellence in learning, discovery, and healing. The nation's fourth-oldest medical school, the Geisel School of Medicine has been home to many firsts in medical education, research and practice, including the discovery of the mechanism for how light resets biological clocks, creating the first multispecialty intensive care unit, the first comprehensive examination of U.S. health care variations (The Dartmouth Atlas), and helping establish the first Center for Health Care Delivery Science, which launched in 2010. As one of America's top medical schools, Dartmouth's Geisel School of Medicine is committed to training new generations of diverse health care leaders who will help solve our most vexing challenges in health care.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 30-Sep-2013
[ | E-mail | Share ]

Contact: Derik Hertel
kenneth.d.hertel@dartmouth.edu
603-650-1211
The Geisel School of Medicine at Dartmouth

Award strengthens pioneering work in cystic fibrosis at Dartmouth's Geisel School of Medicine

Hanover, N.H.The National Institutes of Health (NIH) has awarded a $5.9 million grant to support an Institutional Development Award (IDeA) Lung Biology Center of Biomedical Research Excellence (COBRE) at the Geisel School of Medicine at Dartmouth.

For the past 10 years, COBRE funding has supported the Center's work, which has contributed not only to our understanding of cystic fibrosis and to the development of patented and patent-pending therapeutic approaches for treating the disease, but to other chronic lung diseases. Lung disease is the third most frequent cause of death in the United States.

Directed by Principal Investigator Bruce Stanton, PhD, professor of microbiology and immunology at Geisel, the Lung Biology Center draws on the expertise and dedication of more than 100 faculty, students, and research associates working in 32 laboratories.

"Continued federal funding for the Lung Biology Center is very important to the Geisel School of Medicine and I applaud Bruce Stanton for his leadership," says Duane Compton, PhD, senior associate dean for research and professor of biochemistry at Geisel. "He has built a center that translates the best basic science into clinical application, and which also supports core facilities that sustain our researchers."

With the federal budget sequester taking a toll on biomedical research nationally, this five-year grant award reflects recognition of the quality of the medical research being done at Dartmouth, and provides the resources necessary to support the core services and pilot programs that will enable the Center to continue its work.

"The Lung Biology Center has spearheaded the development and mentoring of a cadre of physician-scientists engaged in cystic fibrosis research," says Stanton. "Their approaches are closely aligned with the goals of the Dartmouth SYNERGY Program in Clinical and Translational Science, which focuses on moving therapeutic advances from the research bench to the patient's bedside."

"This NIH grant demonstrates the strength of Geisel's overall research enterprise, and the excellent discovery taking place around cystic fibrosis and other chronic lung diseases," says Wiley "Chip" Souba, MD, MBA, ScD, dean of Dartmouth's Geisel School of Medicine. "While the sequester is forcing research cuts at many universities, research funding to the medical school just reached an all-time high, with $140 million in total grant funding for fiscal year 2013."

The Lung Biology Center is one of four Dartmouth Centers receiving COBRE support from the National Institute of General Medical Sciences Institutional Development Award Program (IDeA). The others include Immunology, Quantitative Biomedical Sciences, and Molecular Epidemiology. All COBRE programs share expertise and experience with each other, with the New Hampshire-INBRE (IDeA Network of Biomedical Research Excellence), and with partner programs at the University of Vermont and the Mt. Desert Island Biological Laboratory in Maine.

The IDeA program builds research capacities in states that historically have had low levels of NIH funding by supporting basic, clinical, and translational research; faculty development; and infrastructure improvements.

###

The Geisel School of Medicine at Dartmouth, founded in 1797, strives to improve the lives of the communities it serves through excellence in learning, discovery, and healing. The nation's fourth-oldest medical school, the Geisel School of Medicine has been home to many firsts in medical education, research and practice, including the discovery of the mechanism for how light resets biological clocks, creating the first multispecialty intensive care unit, the first comprehensive examination of U.S. health care variations (The Dartmouth Atlas), and helping establish the first Center for Health Care Delivery Science, which launched in 2010. As one of America's top medical schools, Dartmouth's Geisel School of Medicine is committed to training new generations of diverse health care leaders who will help solve our most vexing challenges in health care.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-09/tgso-dr093013.php

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Firm targets Irish abroad as 80 new jobs announced

Managing Partner Mike McKerr, Partner Julie Fenton and Minister Bruton

PROFESSIONAL SERVICES FIRM EY has announced 80 new jobs across its offices in Dublin, Cork, Limerick and Belfast ? with recruitment to take place over the next six months.

The company ? which provides Assurance, Advisory, Tax and Transaction Services ? says the expansion comes after they secured a number of new clients.

Managing Partner Mike McKerr said they hoped to attract local talent, but would also be ?reaching out? to those who have emigrated to Australia, America, South Africa and elsewhere to ??come home? and build a future with EY?

?We have already commenced a targeted recruitment campaign in these locations,? McKerr said.

Welcoming the news, Jobs Minister Richard Bruton said the recruitment campaign targeting Irish people living abroad was ?a strong sign of the progress we are making?.

?I am determined to ensure that, with the proper supports from Government, we can see many more investments like this over the coming months and years,? the Minister added.

The firm is seeking to fill roles for qualified accountants and senior executives as well as ?a number of key roles in the Financial Accounting Advisory and Fraud Investigations and Dispute Services?.

Consultants are also being sought for EY?s advisory team, to support services like cost reduction, risk, change management and IT transformation projects.

In addition to the jobs announcement, the company is also offering 160 graduate positions for their 2014 intake.

Read: Nursing home says it will create 120 new jobs in the next three months >

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Source: http://businessetc.thejournal.ie/jobs-ey-emigrants-1106775-Sep2013/

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Infertile woman gives birth after boost to ovaries

A baby boy has been born following a new fertility treatment that awakens dormant eggs in women who have stopped menstruating.

The treatment could help women who have left child-bearing too late, or have been left infertile after treatment for cancer. But some have raised concerns that the technique has been rushed to the clinic before being properly tested.

Women are born with millions of immature eggs, or follicles, but only around 400 mature to the point where an egg is released into the fallopian tubes and could be fertilised. But some of these follicles remain, even after a woman has stopped menstruating.

Now researchers have found a way to wake these dormant follicles and produce eggs that are capable of being fertilised. The first test of this technique has resulted in a baby boy, born in December 2012 in Japan.

Chop and change

Immature follicles are usually kept in a dormant state by the PTEN gene, which suppresses a signalling pathway involved in cell growth. Aaron Hsueh at Stanford University Medical School in California and his colleagues had previously showed that immature mouse follicles could be stimulated to mature if pieces of ovary were incubated with a molecule that stimulates the signalling pathway that PTEN inhibits.

Hsueh's team also discovered that the physical act of cutting up the ovaries disrupts a second signalling pathway, called the Hippo pathway, which normally suppresses the growth of many of the body's other organs as well.

When the cut up and incubated tissue was implanted back into the mice, eggs were released and fertilised, resulting in the birth of live pups.

Now the team has used a similar process to give women with premature menopause a shot at being mothers, using their own eggs.

Follicle growth

Twenty-seven women who had been diagnosed with premature menopause volunteered to have their ovaries removed. Of these, only 13 had any residual follicles left. These women had their ovaries diced up and incubated with a PTEN inhibitor, before pieces were transplanted into their fallopian tubes. Ultrasound was used to monitor follicle growth.

In all, eight of the women produced mature follicles, and were given drugs to trigger the release of an egg. Five of them produced mature eggs which were harvested and fertilised by IVF. So far, three have had their embryos implanted, resulting in one birth and one on-going pregnancy. The third failed to implant.

Ultimately, Hsueh says the technique could be used to help women who have stopped menstruating, and may not be responding to conventional treatment. "This data shows that there are small follicles still sitting there after women have stopped menstruating. This is a way that you can get them to work."

However, Evelyn Telfer, a fertility researcher at the University of Edinburgh, UK, says much more work is needed to ensure the technique is safe before it is routinely used in the clinic. "It's an interesting first step, but we need to do many controlled studies ? without implanting the embryos ? to show that at each stage of the procedure these eggs are normal," she says. "People say it's a baby at all costs, but if the baby is compromised in any way then that's a problem."

It's also not clear whether the women would have produced mature follicles, and ultimately eggs, if their ovaries had been diced up and re-implanted without exposing them to a PTEN inhibitor.

Journal reference: PNAS, DOI: 10.1073/pnas.1312830110

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